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Acetylcholine Synthesis and Metabolism
Acetyl-CoA is synthesized from pyruvate by mitochondria within cholinergic nerves. This acetyl-CoA combines with choline that is transported into the nerve axon to form acetylcholine (ACh). The enzyme responsible for this is choline acetyltransferase. The newly formed ACh is then transported into vesicles for storage and subsequent release similar to what occurs for NE. After ACh is released, it is rapidly degraded within the synapse by acetylcholineesterase, to form acetate and choline.
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